Details of the Drug

General Information of Drug (ID: DMU3IET)

Drug Name
Thiethylperazine
Synonyms
ETHYLTHIOPERAZINE; Theithylperazine; Thiethylperazinum; Thiethylpipezazine; Thioethylperazine; Tietilperazina; Torecan; Tietilperazina [DCIT]; Thiethylperazinum [INN-Latin]; Torecan (TN); Thiethylperazine (USAN/INN); Thiethylperazine [USAN:INN:BAN]; Norzine (*Dimaleate*); GS-95 (*Dimaleate*)
Indication
Disease Entry ICD 11 Status REF
Nausea MD90 Approved [1], [2]
Therapeutic Class
Antiemetics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 399.6
Topological Polar Surface Area (xlogp) 5.4
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C22H29N3S2
IUPAC Name
2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
Canonical SMILES
CCSC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCN(CC4)C
InChI
InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3
InChIKey
XCTYLCDETUVOIP-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
5440
ChEBI ID
CHEBI:9544
CAS Number
1420-55-9
DrugBank ID
DB00372
TTD ID
D0Y0ER

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Antagonist [3], [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Nausea
ICD Disease Classification MD90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dopamine D2 receptor (D2R) DTT DRD2 2.50E-02 -0.08 -0.49
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Thiethylperazine
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Dimenhydrinate DM264B3 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Dimenhydrinate. Nausea/vomiting [MD90] [15]
Promethazine DM6I5GR Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Promethazine. Nausea/vomiting [MD90] [15]
Metoclopramide DMFA5MY Major Additive antidopaminergic effects by the combination of Thiethylperazine and Metoclopramide. Nausea/vomiting [MD90] [16]
Coadministration of a Drug Treating the Disease Different from Thiethylperazine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Scopolamine DMOM8AL Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Scopolamine. Addictive disorder [6C50-6C5Z] [15]
Mepyramine DMB4SFH Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Mepyramine. Allergic/hypersensitivity disorder [4A80-4A8Z] [17]
Phenyltoloxamine DMKAEQW Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Phenyltoloxamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [17]
Memantine DMD9WSC Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Memantine. Alzheimer disease [8A20] [15]
Galantamine DMEO794 Moderate Antagonize the effect of Thiethylperazine when combined with Galantamine. Alzheimer disease [8A20] [18]
Rivastigmine DMG629M Moderate Antagonize the effect of Thiethylperazine when combined with Rivastigmine. Alzheimer disease [8A20] [18]
Donepezil DMIYG7Z Moderate Antagonize the effect of Thiethylperazine when combined with Donepezil. Alzheimer disease [8A20] [18]
Amyl nitrite DMJKO05 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Amyl nitrite. Angina pectoris [BA40] [19]
Nifedipine DMSVOZT Moderate Additive hypotensive effects by the combination of Thiethylperazine and Nifedipine. Angina pectoris [BA40] [19]
Hydroxyzine DMF8Y74 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Hydroxyzine. Anxiety disorder [6B00-6B0Z] [15]
Ephedrine DMMV0KW Moderate Antagonize the effect of Thiethylperazine when combined with Ephedrine. Asthma [CA23] [20]
Lisdexamfetamine DM6W8V5 Moderate Antagonize the effect of Thiethylperazine when combined with Lisdexamfetamine. Attention deficit hyperactivity disorder [6A05] [20]
Methylphenidate DM7SJD6 Moderate Antagonize the effect of Thiethylperazine when combined with Methylphenidate. Attention deficit hyperactivity disorder [6A05] [20]
Desipramine DMT2FDC Moderate Increased plasma concentrations of Thiethylperazine and Desipramine due to competitive inhibition of the same metabolic pathway. Attention deficit hyperactivity disorder [6A05] [21]
Linezolid DMGFPU2 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Linezolid. Bacterial infection [1A00-1C4Z] [22]
Cariprazine DMJYDVK Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Cariprazine. Bipolar disorder [6A60] [15]
Loperamide DMOJZQ9 Moderate Additive antimotility effects by the combination of Thiethylperazine and Loperamide. Bowel habit change [ME05] [23]
Sotalol DML60TN Moderate Additive hypotensive effects by the combination of Thiethylperazine and Sotalol. Cardiac arrhythmia [BC9Z] [19]
Acetylcholine DMDF79Z Moderate Antagonize the effect of Thiethylperazine when combined with Acetylcholine. Cataract [9B10] [24]
Umeclidinium DM4E8O9 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Umeclidinium. Chronic obstructive pulmonary disease [CA22] [25]
Tiotropium DMFDC0Q Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Tiotropium. Chronic obstructive pulmonary disease [CA22] [25]
Revefenacin DMMP5SI Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Revefenacin. Chronic obstructive pulmonary disease [CA22] [25]
Olopatadine DMKMWQG Moderate Additive CNS depression effects by the combination of Thiethylperazine and Olopatadine. Conjunctiva disorder [9A60] [26]
Nimodipine DMQ0RKZ Moderate Additive hypotensive effects by the combination of Thiethylperazine and Nimodipine. Coronary vasospastic disease [BA85] [19]
Trimipramine DM1SC8M Moderate Increased plasma concentrations of Thiethylperazine and Trimipramine due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [21]
Cyclobenzaprine DM1YBRM Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Cyclobenzaprine. Depression [6A70-6A7Z] [15]
Imipramine DM2NUH3 Moderate Increased plasma concentrations of Thiethylperazine and Imipramine due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [21]
Fluoxetine DM3PD2C Moderate Additive antidopaminergic effects by the combination of Thiethylperazine and Fluoxetine. Depression [6A70-6A7Z] [27]
Nortriptyline DM4KDYJ Moderate Increased plasma concentrations of Thiethylperazine and Nortriptyline due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [21]
Paroxetine DM5PVQE Moderate Decreased metabolism of Thiethylperazine caused by Paroxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [28]
Selegiline DM6034S Moderate Additive hypotensive effects by the combination of Thiethylperazine and Selegiline. Depression [6A70-6A7Z] [22]
Duloxetine DM9BI7M Moderate Decreased metabolism of Thiethylperazine caused by Duloxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [29]
Isocarboxazid DMAF1NB Moderate Additive hypotensive effects by the combination of Thiethylperazine and Isocarboxazid. Depression [6A70-6A7Z] [22]
Tranylcypromine DMGB5RE Moderate Additive CNS depression effects by the combination of Thiethylperazine and Tranylcypromine. Depression [6A70-6A7Z] [30]
OPC-34712 DMHG57U Moderate Additive anticholinergic effects by the combination of Thiethylperazine and OPC-34712. Depression [6A70-6A7Z] [15]
Phenelzine DMHIDUE Moderate Additive hypotensive effects by the combination of Thiethylperazine and Phenelzine. Depression [6A70-6A7Z] [22]
Clomipramine DMINRKW Moderate Increased plasma concentrations of Thiethylperazine and Clomipramine due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [21]
Amoxapine DMKITQE Moderate Increased plasma concentrations of Thiethylperazine and Amoxapine due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [21]
Doxepin DMPI98T Moderate Increased plasma concentrations of Thiethylperazine and Doxepin due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [21]
Maprotiline DMPWB7T Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Maprotiline. Depression [6A70-6A7Z] [15]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Thiethylperazine and Esketamine. Depression [6A70-6A7Z] [31]
Nitroglycerin DMQ2491 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Nitroglycerin. Diabetic foot ulcer [BD54] [19]
Hyoscyamine DM804UR Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Hyoscyamine. Digestive system disease [DE2Z] [15]
Mepenzolate DM8YU2F Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Mepenzolate. Digestive system disease [DE2Z] [17]
Oxybutynine DMJPBAX Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Oxybutynine. Discovery agent [N.A.] [15]
Tetrabenazine DMYWQ0O Major Increased risk of prolong QT interval by the combination of Thiethylperazine and Tetrabenazine. Dissociative neurological symptom disorder [6B60] [32]
Meclizine DMS7T13 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Meclizine. Dizziness and giddiness [MB48] [15]
Trihexyphenidyl DMB19L8 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Trihexyphenidyl. Dystonic disorder [8A02] [15]
Deutetrabenazine DMUPFLI Major Increased risk of prolong QT interval by the combination of Thiethylperazine and Deutetrabenazine. Dystonic disorder [8A02] [33]
Zonisamide DM0DTF7 Major Additive CNS depression effects by the combination of Thiethylperazine and Zonisamide. Epilepsy/seizure [8A61-8A6Z] [34]
Diphenhydramine DMKQTBA Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Diphenhydramine. Episodic vestibular syndrome [AB31] [15]
Timolol DM3NXRU Moderate Additive hypotensive effects by the combination of Thiethylperazine and Timolol. Essential hypertension [BA00] [19]
Guanabenz DM5QWEL Moderate Additive hypotensive effects by the combination of Thiethylperazine and Guanabenz. Essential hypertension [BA00] [35]
Phenoxybenzamine DM8KSQH Moderate Additive hypotensive effects by the combination of Thiethylperazine and Phenoxybenzamine. Essential hypertension [BA00] [19]
Nicardipine DMCDYW7 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Nicardipine. Essential hypertension [BA00] [19]
Mecamylamine DMGQFYB Moderate Additive hypotensive effects by the combination of Thiethylperazine and Mecamylamine. Essential hypertension [BA00] [19]
Nadolol DMW6GVL Moderate Additive hypotensive effects by the combination of Thiethylperazine and Nadolol. Essential hypertension [BA00] [19]
Solifenacin DMG592Q Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Solifenacin. Functional bladder disorder [GC50] [15]
Tolterodine DMSHPW8 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Tolterodine. Functional bladder disorder [GC50] [15]
Darifenacin DMWXLYZ Moderate Decreased metabolism of Thiethylperazine caused by Darifenacin mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [36]
Terbinafine DMI6HUW Moderate Decreased metabolism of Thiethylperazine caused by Terbinafine mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [37]
Phentolamine DMXYJOB Moderate Additive hypotensive effects by the combination of Thiethylperazine and Phentolamine. Gangrene [MC85] [19]
Brimonidine DMQLT4N Moderate Additive CNS depression effects by the combination of Thiethylperazine and Brimonidine. Glaucoma [9C61] [38]
Pilocarpine DMV9ADG Moderate Antagonize the effect of Thiethylperazine when combined with Pilocarpine. Glaucoma [9C61] [24]
Spironolactone DM2AQ5N Moderate Additive hypotensive effects by the combination of Thiethylperazine and Spironolactone. Heart failure [BD10-BD1Z] [19]
Triamterene DM2HU9I Moderate Additive hypotensive effects by the combination of Thiethylperazine and Triamterene. Heart failure [BD10-BD1Z] [19]
Prazosin DMCD9YG Moderate Additive hypotensive effects by the combination of Thiethylperazine and Prazosin. Heart failure [BD10-BD1Z] [19]
Eplerenone DMF0NQR Moderate Additive hypotensive effects by the combination of Thiethylperazine and Eplerenone. Heart failure [BD10-BD1Z] [19]
Carvedilol DMHTEAO Moderate Additive hypotensive effects by the combination of Thiethylperazine and Carvedilol. Heart failure [BD10-BD1Z] [19]
Chlorothiazide DMLHESP Moderate Additive hypotensive effects by the combination of Thiethylperazine and Chlorothiazide. Heart failure [BD10-BD1Z] [19]
Furosemide DMMQ8ZG Moderate Additive hypotensive effects by the combination of Thiethylperazine and Furosemide. Heart failure [BD10-BD1Z] [19]
Amiloride DMRTSGP Moderate Additive hypotensive effects by the combination of Thiethylperazine and Amiloride. Heart failure [BD10-BD1Z] [19]
Bumetanide DMRV7H0 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Bumetanide. Heart failure [BD10-BD1Z] [19]
Hydroflumethiazide DMVPUQI Moderate Additive hypotensive effects by the combination of Thiethylperazine and Hydroflumethiazide. Heart failure [BD10-BD1Z] [35]
Procarbazine DMIK367 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Procarbazine. Hodgkin lymphoma [2B30] [22]
Ritonavir DMU764S Moderate Decreased metabolism of Thiethylperazine caused by Ritonavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [39]
Isosorbide mononitrate DMYLMU0 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Isosorbide mononitrate. Hydrocephalus [8D64] [19]
Eprosartan DM07K2I Moderate Additive hypotensive effects by the combination of Thiethylperazine and Eprosartan. Hypertension [BA00-BA04] [19]
Acebutolol DM0TI4U Moderate Additive hypotensive effects by the combination of Thiethylperazine and Acebutolol. Hypertension [BA00-BA04] [19]
Moexipril DM26E4B Moderate Additive hypotensive effects by the combination of Thiethylperazine and Moexipril. Hypertension [BA00-BA04] [19]
Bisoprolol DM3UZ95 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Bisoprolol. Hypertension [BA00-BA04] [19]
Captopril DM458UM Moderate Additive hypotensive effects by the combination of Thiethylperazine and Captopril. Hypertension [BA00-BA04] [19]
Trandolapril DM4L6EU Moderate Additive hypotensive effects by the combination of Thiethylperazine and Trandolapril. Hypertension [BA00-BA04] [19]
Methyldopa DM5I621 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Methyldopa. Hypertension [BA00-BA04] [19]
Clonidine DM6RZ9Q Moderate Additive hypotensive effects by the combination of Thiethylperazine and Clonidine. Hypertension [BA00-BA04] [19]
Losartan DM72JXH Moderate Additive hypotensive effects by the combination of Thiethylperazine and Losartan. Hypertension [BA00-BA04] [19]
Nebivolol DM7F1PA Moderate Additive hypotensive effects by the combination of Thiethylperazine and Nebivolol. Hypertension [BA00-BA04] [19]
Nisoldipine DM7ISKJ Moderate Additive hypotensive effects by the combination of Thiethylperazine and Nisoldipine. Hypertension [BA00-BA04] [19]
Levamlodipine DM92S6N Moderate Additive hypotensive effects by the combination of Thiethylperazine and Levamlodipine. Hypertension [BA00-BA04] [19]
Fosinopril DM9NJ52 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Fosinopril. Hypertension [BA00-BA04] [19]
Doxazosin DM9PLRH Moderate Additive hypotensive effects by the combination of Thiethylperazine and Doxazosin. Hypertension [BA00-BA04] [19]
Verapamil DMA7PEW Moderate Additive hypotensive effects by the combination of Thiethylperazine and Verapamil. Hypertension [BA00-BA04] [19]
Amlodipine DMBDAZV Moderate Additive hypotensive effects by the combination of Thiethylperazine and Amlodipine. Hypertension [BA00-BA04] [19]
Pindolol DMD2NV7 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Pindolol. Hypertension [BA00-BA04] [19]
Fenoldopam DMFAOKP Moderate Additive hypotensive effects by the combination of Thiethylperazine and Fenoldopam. Hypertension [BA00-BA04] [19]
Indapamide DMGN1PW Moderate Additive hypotensive effects by the combination of Thiethylperazine and Indapamide. Hypertension [BA00-BA04] [19]
Benazepril DMH1M9B Moderate Additive hypotensive effects by the combination of Thiethylperazine and Benazepril. Hypertension [BA00-BA04] [19]
Labetalol DMK8U72 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Labetalol. Hypertension [BA00-BA04] [19]
Diazoxide DML1538 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Diazoxide. Hypertension [BA00-BA04] [19]
Enalapril DMNFUZR Moderate Additive hypotensive effects by the combination of Thiethylperazine and Enalapril. Hypertension [BA00-BA04] [19]
Perindopril DMOPZDT Moderate Additive hypotensive effects by the combination of Thiethylperazine and Perindopril. Hypertension [BA00-BA04] [19]
Quinapril DMR8H31 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Quinapril. Hypertension [BA00-BA04] [19]
Telmisartan DMS3GX2 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Telmisartan. Hypertension [BA00-BA04] [19]
Irbesartan DMTP1DC Moderate Additive hypotensive effects by the combination of Thiethylperazine and Irbesartan. Hypertension [BA00-BA04] [19]
Hydralazine DMU8JGH Moderate Additive hypotensive effects by the combination of Thiethylperazine and Hydralazine. Hypertension [BA00-BA04] [19]
Lisinopril DMUOK4C Moderate Additive hypotensive effects by the combination of Thiethylperazine and Lisinopril. Hypertension [BA00-BA04] [19]
Hydrochlorothiazide DMUSZHD Moderate Additive hypotensive effects by the combination of Thiethylperazine and Hydrochlorothiazide. Hypertension [BA00-BA04] [19]
Clevidipine butyrate DMW4M97 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Clevidipine butyrate. Hypertension [BA00-BA04] [19]
Belladonna DM2RBWK Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Belladonna. Infectious gastroenteritis/colitis [1A40] [15]
ITI-007 DMUQ1DO Moderate Additive anticholinergic effects by the combination of Thiethylperazine and ITI-007. Insomnia [7A00-7A0Z] [15]
Polyethylene glycol DM4I1JP Moderate Increased risk of lowers seizure threshold by the combination of Thiethylperazine and Polyethylene glycol. Irritable bowel syndrome [DD91] [40]
Clidinium DMUMQZ0 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Clidinium. Irritable bowel syndrome [DD91] [15]
Dicyclomine DMZSDGX Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Dicyclomine. Irritable bowel syndrome [DD91] [15]
Physostigmine DM2N0TO Moderate Antagonize the effect of Thiethylperazine when combined with Physostigmine. Lips/oral mucosa miscellaneous disorder [DA02] [18]
Porfimer Sodium DM7ZWNY Moderate Increased risk of photosensitivity reactions by the combination of Thiethylperazine and Porfimer Sodium. Lung cancer [2C25] [41]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Thiethylperazine and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [42]
Propranolol DM79NTF Moderate Additive hypotensive effects by the combination of Thiethylperazine and Propranolol. Migraine [8A80] [19]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Thiethylperazine and Lasmiditan. Migraine [8A80] [43]
Flibanserin DM70DTN Moderate Additive CNS depression effects by the combination of Thiethylperazine and Flibanserin. Mood disorder [6A60-6E23] [44]
Thalidomide DM70BU5 Moderate Additive CNS depression effects by the combination of Thiethylperazine and Thalidomide. Multiple myeloma [2A83] [26]
Ozanimod DMT6AM2 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Ozanimod. Multiple sclerosis [8A40] [22]
Methoxsalen DME8FZ9 Moderate Increased risk of photosensitivity reactions by the combination of Thiethylperazine and Methoxsalen. Mycosis fungoides [2B01] [31]
Imatinib DM7RJXL Moderate Decreased metabolism of Thiethylperazine caused by Imatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [45]
Dextroamphetamine DMMIHVP Moderate Antagonize the effect of Thiethylperazine when combined with Dextroamphetamine. Narcolepsy [7A20] [20]
Bupropion DM5PCS7 Major Decreased metabolism of Thiethylperazine caused by Bupropion mediated inhibition of CYP450 enzyme. Nicotine use disorder [6C4A] [46]
Phendimetrazine DM6TS1N Moderate Antagonize the effect of Thiethylperazine when combined with Phendimetrazine. Obesity [5B80-5B81] [20]
Amfepramone DM9YSNQ Moderate Antagonize the effect of Thiethylperazine when combined with Amfepramone. Obesity [5B80-5B81] [20]
Lorcaserin DMG6OYJ Moderate Increased risk of hyperprolactinemic effects by the combination of Thiethylperazine and Lorcaserin. Obesity [5B80-5B81] [47]
Benzphetamine DMIJATC Moderate Antagonize the effect of Thiethylperazine when combined with Benzphetamine. Obesity [5B80-5B81] [20]
Phenylpropanolamine DMTFK3O Moderate Antagonize the effect of Thiethylperazine when combined with Phenylpropanolamine. Obesity [5B80-5B81] [48]
Metolazone DMB39LO Moderate Additive hypotensive effects by the combination of Thiethylperazine and Metolazone. Oedema [MG29] [19]
Polythiazide DMCH80F Moderate Additive hypotensive effects by the combination of Thiethylperazine and Polythiazide. Oedema [MG29] [35]
Lofexidine DM1WXA6 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Lofexidine. Opioid use disorder [6C43] [19]
Apraclonidine DMO4PVE Moderate Additive CNS depression effects by the combination of Thiethylperazine and Apraclonidine. Optic nerve disorder [9C40] [38]
Dextropropoxyphene DM23HCX Major Additive CNS depression effects by the combination of Thiethylperazine and Dextropropoxyphene. Pain [MG30-MG3Z] [49]
Flavoxate DMKV4NL Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Flavoxate. Pain [MG30-MG3Z] [15]
Methamphetamine DMPM4SK Moderate Antagonize the effect of Thiethylperazine when combined with Methamphetamine. Pain [MG30-MG3Z] [48]
Meperidine DMX4GND Moderate Additive CNS depression effects by the combination of Thiethylperazine and Meperidine. Pain [MG30-MG3Z] [50]
Safinamide DM0YWJC Moderate Additive hypotensive effects by the combination of Thiethylperazine and Safinamide. Parkinsonism [8A00] [22]
Pergolide DM14MAE Moderate Antagonize the effect of Thiethylperazine when combined with Pergolide. Parkinsonism [8A00] [51]
Opicapone DM1BKA6 Moderate Additive CNS depression effects by the combination of Thiethylperazine and Opicapone. Parkinsonism [8A00] [52]
Rasagiline DM3WKQ4 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Rasagiline. Parkinsonism [8A00] [22]
Biperiden DME78OA Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Biperiden. Parkinsonism [8A00] [17]
Procyclidine DMHFJDT Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Procyclidine. Parkinsonism [8A00] [17]
Entacapone DMLBVKQ Moderate Antagonize the effect of Thiethylperazine when combined with Entacapone. Parkinsonism [8A00] [51]
Levodopa DMN3E57 Moderate Antagonize the effect of Thiethylperazine when combined with Levodopa. Parkinsonism [8A00] [51]
Pramipexole DMNMW9R Moderate Antagonize the effect of Thiethylperazine when combined with Pramipexole. Parkinsonism [8A00] [51]
Bromocriptine DMVE3TK Moderate Antagonize the effect of Thiethylperazine when combined with Bromocriptine. Parkinsonism [8A00] [51]
Orphenadrine DMW542E Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Orphenadrine. Parkinsonism [8A00] [15]
Apomorphine DMX38HQ Moderate Antagonize the effect of Thiethylperazine when combined with Apomorphine. Parkinsonism [8A00] [53]
Lindane DMB8CNL Moderate Increased risk of lowers seizure threshold by the combination of Thiethylperazine and Lindane. Pediculosis [1G00] [54]
Methylscopolamine DM5VWOB Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Methylscopolamine. Peptic ulcer [DA61] [15]
ABIRATERONE DM8V75C Moderate Decreased metabolism of Thiethylperazine caused by ABIRATERONE mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [55]
Terazosin DM3JCVS Moderate Additive hypotensive effects by the combination of Thiethylperazine and Terazosin. Prostate hyperplasia [GA90] [19]
Tamsulosin DM5QF9V Moderate Additive hypotensive effects by the combination of Thiethylperazine and Tamsulosin. Prostate hyperplasia [GA90] [19]
Silodosin DMJSBT6 Moderate Additive hypotensive effects by the combination of Thiethylperazine and Silodosin. Prostate hyperplasia [GA90] [19]
Verteporfin DMIY6DB Moderate Increased risk of photosensitivity reactions by the combination of Thiethylperazine and Verteporfin. Psoriasis [EA90] [56]
Fluphenazine DMIT8LX Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Fluphenazine. Psychotic disorder [6A20-6A25] [15]
Neupro DMHEAB1 Moderate Antagonize the effect of Thiethylperazine when combined with Neupro. Restless legs syndrome [7A80] [51]
Celecoxib DM6LOQU Moderate Decreased metabolism of Thiethylperazine caused by Celecoxib mediated inhibition of CYP450 enzyme. Rheumatoid arthritis [FA20] [57]
Cyproheptadine DM92AH3 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Cyproheptadine. Rheumatoid arthritis [FA20] [15]
Quetiapine DM1N62C Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Quetiapine. Schizophrenia [6A20] [15]
Mesoridazine DM2ZGAN Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Mesoridazine. Schizophrenia [6A20] [17]
Thioridazine DM35M8J Major Increased risk of prolong QT interval by the combination of Thiethylperazine and Thioridazine. Schizophrenia [6A20] [58]
Aripiprazole DM3NUMH Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Aripiprazole. Schizophrenia [6A20] [15]
Iloperidone DM6AUFY Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Iloperidone. Schizophrenia [6A20] [15]
Loxapine DM8AI9U Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Loxapine. Schizophrenia [6A20] [15]
Haloperidol DM96SE0 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Haloperidol. Schizophrenia [6A20] [15]
Perphenazine DMA4MRX Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Perphenazine. Schizophrenia [6A20] [15]
Molindone DMAH70G Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Molindone. Schizophrenia [6A20] [15]
Chlorpromazine DMBGZI3 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Chlorpromazine. Schizophrenia [6A20] [15]
Thiothixene DMDINC4 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Thiothixene. Schizophrenia [6A20] [15]
Trifluoperazine DMKBYWI Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Trifluoperazine. Schizophrenia [6A20] [15]
Risperidone DMN6DXL Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Risperidone. Schizophrenia [6A20] [15]
Asenapine DMSQZE2 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Asenapine. Schizophrenia [6A20] [15]
Pimozide DMW83TP Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Pimozide. Schizophrenia [6A20] [15]
Papaverine DMCA9QP Moderate Additive hypotensive effects by the combination of Thiethylperazine and Papaverine. Tonus and reflex abnormality [MB47] [19]
Tizanidine DMR2IQ4 Moderate Additive CNS depression effects by the combination of Thiethylperazine and Tizanidine. Tonus and reflex abnormality [MB47] [59]
Atropine DMEN6X7 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Atropine. Unspecific substance harmful effect [NE6Z] [15]
Chlorpheniramine DM5URA2 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Chlorpheniramine. Vasomotor/allergic rhinitis [CA08] [15]
Triprolidine DM7SWIA Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Triprolidine. Vasomotor/allergic rhinitis [CA08] [15]
Carbinoxamine DMCT31R Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Carbinoxamine. Vasomotor/allergic rhinitis [CA08] [15]
Brompheniramine DMFOVSD Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Brompheniramine. Vasomotor/allergic rhinitis [CA08] [15]
Dexbrompheniramine DMKVWGE Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Dexbrompheniramine. Vasomotor/allergic rhinitis [CA08] [15]
Acrivastine DMTIGA0 Moderate Additive anticholinergic effects by the combination of Thiethylperazine and Acrivastine. Vasomotor/allergic rhinitis [CA08] [17]
⏷ Show the Full List of 185 DDI Information of This Drug

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